Recent publications

Raphael Roccor , Megan E. Wolf, Jie Liu, Lindsay D. Eltis (2024). The catabolism of ethylene glycol by Rhodococcus jostii RHA1 and its dependence on mycofactocin. Appl Environ Microbiol.

DOI

Megan E. Wolf, Anne T. Lalande, Brianne L. Newman, Alissa C. Bleem, Chad T. Palumbo, Gregg T. Beckham, Lindsay D. Eltis (2024). The catabolism of lignin-derived p-methoxylated aromatic compounds by Rhodococcus jostii RHA1. Appl Environ Microbiol.

DOI

Kirstin L. Brown, Jessica M. C. Krekhno, Shipei Xing, Tao Huan, Lindsay D. Eltis (2023). Cholesterol-Mediated Coenzyme A Depletion in Catabolic Mutants of Mycobacteria Leads to Toxicity. ACS Infect Dis.

DOI

Jason C. Grigg, Janine N. Copp, Jessica M. C. Krekhno, Jie Liu, Aygun Ibrahimova, Lindsay D. Eltis (2023). Deciphering the biosynthesis of a novel lipid in Mycobacterium tuberculosis expands the known roles of the nitroreductase superfamily. J Biol Chem.

DOI

Kirstin L. Brown, Kaley M. Wilburn, Christine R. Montague, Jason C. Grigg, Olalla Sanz, Esther Pérez-Herrán, David Barros, Lluís Ballell, Brian C. VanderVen, Lindsay D. Eltis (2023). Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism in Mycobacterium tuberculosis by the Novel Drug Candidate GSK2556286. Antimicrob Agents Chemother.

DOI

Gara N. Dexter, Laura E. Navas, Jason C. Grigg, Harbir Bajwa, David J. Levy-Booth, Jie Liu, Nathan A. Louie, Seyed A. Nasseri, Soo-Kyeong Jang, Scott Renneckar, Lindsay D. Eltis, William W. Mohn (2022). Bacterial catabolism of acetovanillone, a lignin-derived compound. Proc. Natl. Acad. Sci. U.S.A..

DOI

Adam M. Crowe, Jessica M. C. Krekhno, Kirstin L. Brown, Jayesh A. Kulkarni, Katherine C. Yam, Lindsay D. Eltis (2022). The unusual convergence of steroid catabolic pathways in Mycobacterium abscessus. Proc. Natl. Acad. Sci. U.S.A..

DOI

Laura E. Navas, Michael Zahn, Harbir Bajwa, Jason C. Grigg, Megan E. Wolf, Anson C.K. Chan, Michael E.P. Murphy, John E. McGeehan, Lindsay D. Eltis (2022). Characterization of a phylogenetically distinct extradiol dioxygenase involved in the bacterial catabolism of lignin-derived aromatic compounds. J Biol Chem.

DOI

James W. Round, Logan D. Robeck, Lindsay D. Eltis (2021). An integrative toolbox for synthetic biology in Rhodococcus.. ACS Synth. Biol..

DOI

Laura E. Navas, Gara Dexter, Jie Liu, David Levy-Booth, MiJung Cho, Soo-Kyeong Jang, Shawn D. Mansfield, Scott Renneckar, William W. Mohn, Lindsay D. Eltis (2021). Bacterial transformation of aromatic monomers in softwood black liquor. Front. Microbiol.

DOI

Megan E. Wolf, Daniel J. Hinchen, Jennifer L. DuBois, John E. McGeehan, Lindsay D. Eltis (2021). Cytochromes P450 in the bacterial valorization of lignin. Curr Op Biotech.

DOI

Eugene Kuatsjah, Anson C. K. Chan, Rui Katahira, Stefan J. Haugen, Gregg T. Beckham, Michael E. P. Murphy, Lindsay D. Eltis (2021). Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J. Biol. Chem..

DOI

Morgan M. Fetherolf, David J. Levy-Booth, Laura E. Navas, Jie Liu, Jason C. Grigg, Andrew Wilson, Rui Katahira, Gregg T. Beckham, William W. Mohn, Lindsay D. Eltis (2020). Characterization of alkylguaiacol-degrading cytochromes P450 for the biocatalytic valorization of lignin. Proc. Natl. Acad. Sci. USA.

DOI

John E. Gadbery, James W. Round, Tianao Yuan, Matthew F. Wipperman, Keith T. Story, Adam M. Crowe, Israel Casabon, Jie Liu, Xinxin Yang, Lindsay D. Eltis, Nicole S. Sampson (2020). IpdE1-IpdE2 is a heterotetrameric acyl coenzyme A dehydrogenase that is widely distributed in steroid-degrading bacteria. Biochemistry.

DOI

Valentina Perna, Anne S. Meyer, Jesper Holck, Lindsay D. Eltis, Vincent G. H. Eijsink, Jane Wittrup Agger (2020). Laccase-catalyzed oxidation of lignin induces production of H₂O₂. ACS Sustainable Chem Eng.

DOI

Johannes Holert, Kirstin Brown, Ameena Hashimi, Lindsay D. Eltis, William W. Mohn (2020). Steryl ester formation and accumulation in steroid-degrading bacteria. Appl Environ Microbiol.

DOI

James W. Round, Raphael Roccor, Lindsay D. Eltis (2019). A biocatalyst for sustainable wax ester production: Re-wiring lipid accumulation in Rhodococcus to yield high-value oleochemicals. Green chem.

DOI

Roland C. Wilhelm, Rahul Singh, Lindsay D. Eltis, William W. Mohn (2019). Bacterial contributions to delignification and lignocellulose degradation in forest soils with metagenomic and quantitative stable isotope probing. ISME J.

DOI

Eugene Kuatsjah, Meghan M. Verstraete, Marek J. Kobylarz, Alvin K. N. Liu, Michael E. P. Murphy, Lindsay D. Eltis (2019). Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. J Biol Chem.

DOI

David J. Levy-Booth, Morgan M. Fetherolf, Gordon R. Stewart, Jie Liu, Lindsay D. Eltis, William W. Mohn (2019). Catabolism of alkylphenols in Rhodococcus via a meta-cleavage pathway associated with genomic islands. Front Microbiol.

DOI

Laura E. Navas, Fernando D. Martinez, Graciela B. Benintende, Marcelo F. Berretta, Laura E. Navas, Maria E. Taverna, Veronica Nicolau, Diana Estenoz, Eleonora Campos, Marcelo F. Berretta, Maria E. Taverna, Diana Estenoz, Maria E. Taverna, Veronica Nicolau, Morgan M. Fetherolf, Lindsay D. Eltis, Eleonora Campos (2019). A thermostable laccase from Thermus sp. 2.9 and its potential for delignification of Eucalyptus biomass. AMB Express.

DOI

Yoshiaki Tamaru, Makoto Yoshida, Lindsay D. Eltis, Barry Goodell (2019). Multiple iron reduction by methoxylated phenolic lignin structures and the generation of reactive oxygen species by lignocellulose surfaces. Int J Biol Macromol.

DOI

Catherine F. M. Bowden, Anson C. K. Chan, Emily J. W. Li, Angele L. Arrieta, Lindsay D. Eltis, Michael E. P. Murphy (2018). Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin. J Biol Chem.

DOI

J. Andrew N. Alexander, Som S. Chatterjee, Stephanie M. Hamilton, Lindsay D. Eltis, Henry F. Chambers, Natalie C. J. Strynadka (2018). Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus. J Biol Chem.

DOI

Jason B. Hedges, Eugene Kuatsjah, Yi-Ling Du, Lindsay D. Eltis, Katherine S. Ryan (2018). Snapshots of the catalytic cycle of an O₂, pyridoxal phosphate-dependent hydroxylase. ACS Chem Biol.

DOI

Eugene Kuatsjah, Anson C. K. Chan, Timothy E. Hurst, Victor Snieckus, Michael E. P. Murphy, Lindsay D. Eltis (2018). Metal- and serine-dependent meta-cleavage product hydrolases utilize similar nucleophile-activation strategies. ACS Catal.

DOI

Adam M. Crowe, Sean D. Workman, Nobuhiko Watanabe, Liam J. Worrall, Natalie C. J. Strynadka, Lindsay D. Eltis (2018). IpdAB, a virulence factor in Mycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase. Proc Natl Acad Sci USA.

DOI

Sven Nerdinger, Eugene Kuatsjah, Timothy E. Hurst, Inge Schlapp-Hackl, Volker Kahlenberg, Klaus Wurst, Lindsay D. Eltis, Victor Snieckus (2018). Bacterial catabolism of biphenyls: Synthesis and evaluation of analogues. ChemBioChem.

DOI

Eugene Kuatsjah, Anson C. K. Chan, Marek J. Kobylarz, Michael E. P. Murphy, Lindsay D. Eltis (2017). The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily. J Biol Chem.

DOI

Rahul Singh, Jinguang Hu, Matthew R. Regner, James W. Round, John Ralph, John N. Saddler, Lindsay D. Eltis (2017). Enhanced delignification of steam-pretreated poplar by a bacterial laccase. Sci Rep.

DOI

Eugene Kuatsjah, Hong-Ming Chen, Stephen G. Withers, Lindsay D. Eltis (2017). Characterization of an extradiol dioxygenase involved in the catabolism of lignin-derived biphenyl. FEBS Lett.

DOI

Adam M. Crowe, Israel Casabon, Kirstin L. Brown, Jie Liu, Jennifer Lian, Jason C. Rogalski, Timothy E. Hurst, Victor Snieckus, Leonard J. Foster, Lindsay D. Eltis (2017). Catabolism of the last two steroid rings in Mycobacterium tuberculosis and other bacteria. mBio.

DOI

James Round, Raphael Roccor, Shu-Nan Li, Lindsay D. Eltis (2017). A fatty acyl coenzyme a reductase promotes wax ester accumulation in Rhodococcus jostii RHA1. Appl Environ Microbiol.

DOI

Anh Thu Ho Ngoc, Stephanie S. Dawes, Adam M. Crowe, Israel Casabon, Chen Gao, Sharon L. Kendall, Edward N. Baker, Lindsay D. Eltis, J. Shaun Lott (2016). The structure of the transcriptional repressor KstR in complex with CoA thioester cholesterol metabolites sheds light on the regulation of cholesterol catabolism in Mycobacterium tuberculosis. J Biol Chem.

DOI

Hiroshi Otani, Peter J. Stogios, Xiaohui Xu, Boguslaw Nocek, Shu-Nan Li, Alexei Savchenko, Lindsay D. Eltis (2016). The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism. Nucleic Acids Res.

DOI

Sonali Dhindwal, Leticia Gomez-Gil, David B. Neau, Thi Thanh My Pham, Michel Sylvestre, Lindsay D. Eltis, Jeffrey T. Bolin, Pravindra Kumar (2016). Structural basis of the enhanced pollutant-degrading capabilities of an engineered biphenyl dioxygenase. J Bacteriol.

DOI

Sawsan Amara, Nicolas Seghezzi, Hiroshi Otani, Carlos Diaz-Salazar, Jie Liu, Lindsay D. Eltis (2016). Characterization of key triacylglycerol biosynthesis processes in rhodococci. Sci Rep.

DOI

Yi-Ling Du, Rahul Singh, Lona M. Alkhalaf, Eugene Kuatsjah, Hai-Yan He, Lindsay D. Eltis, Katherine S. Ryan (2016). A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nat Chem Biol.

DOI

Rahul Singh, Lindsay D. Eltis (2015). The multihued palette of dye-decolorizing peroxidases. Arch Biochem Biophys.

DOI

Song-Hua Zhu, Jens Reuther, Jie Liu, Fiona H. Crocker, Karl J. Indest, Lindsay D. Eltis, William W. Mohn (2015). The essential role of nitrogen limitation in expression of xpla and degradation of hexahydro-1,3,5-trinitro-1,3,5-triazine (rdx) in gordonia sp. Strain ktr9. Appl Microbiol Biotechnol.

DOI

Adam M. Crowe, Peter J. Stogios, Israel Casabon, Elena Evdokimova, Alexei Savchenko, Lindsay D. Eltis (2015). Structural and functional characterization of a ketosteroid transcriptional regulator of mycobacterium tuberculosis. J Biol Chem.

DOI

Brian C. Vander Ven, Ruth J. Fahey, Wonsik Lee, Yancheng Liu, Robert B. Abramovitch, Christine Memmott, Adam M. Crowe, Lindsay D. Eltis, Emanuele Perola, David D. Deininger, Tiansheng Wang, Christopher P. Locher, David G. Russell (2015). Novel inhibitors of cholesterol degradation in mycobacterium tuberculosis reveal how the bacterium’s metabolism is constrained by the intracellular environment. PLoS Pathog.

DOI

Alvaro Barrientos, Estefania Merino, Israel Casabon, Joaquin Rodriguez, Adam M. Crowe, Johannes Holert, Bodo Philipp, Lindsay D. Eltis, Elias R. Olivera, Jose M. Luengo (2015). Functional analyses of three acyl-coa synthetases involved in bile acid degradation in pseudomonas putida doc21. Environ Microbiol.

DOI

Justyna K. Kulig, Claudia Spandolf, Ralph Hyde, Antonio C. Ruzzini, Lindsay D. Eltis, Gunnar Groenberg, Martin A. Hayes, Gideon Grogan (2015). A p450 fusion library of heme domains from rhodococcus jostii rha1 and its evaluation for the biotransformation of drug molecules. Bioorg Med Chem.

DOI

Jonathan S. Penfield, Liam J. Worrall, Natalie C. Strynadka, Lindsay D. Eltis (2014). Substrate specificities and conformational flexibility of 3-ketosteroid 9α-hydroxylases. J Biol Chem.

DOI

Cameron R. Strachan, Rahul Singh, David Van Insberghe, Kateryna Ievdokymenko, Karen Budwill, William W. Mohn, Lindsay D. Eltis, Steven J. Hallam (2014). Metagenomic scaffolds enable combinatorial lignin transformation. Proc Natl Acad Sci USA.

DOI

Catherine F. M. Bowden, Meghan M. Verstraete, Lindsay D. Eltis, Michael E. P. Murphy (2014). Hemoglobin binding and catalytic heme extraction by isdb near iron transporter domains. Biochemistry.

DOI

Hiroshi Otani, Young-Eun Lee, Israel Casabon, Lindsay D. Eltis (2014). Characterization of p-hydroxycinnamate catabolism in a soil actinobacterium. J Bacteriol.

DOI

Israel Casabon, Kendra Swain, Adam M. Crowe, Lindsay D. Eltis, William W. Mohn (2014). Actinobacterial acyl coenzyme a synthetases involved in steroid side-chain catabolism. J Bacteriol.

DOI

Ute Haussmann, Dirk A. Wolters, Benjamin Fraenzel, Lindsay D. Eltis, Ansgar Poetsch (2013). Physiological adaptation of the rhodococcus jostii rha1 membrane proteome to steroids as growth substrates. J Proteome Res.

DOI

Antonio C. Ruzzini, Shiva Bhowmik, Katherine C. Yam, Subhangi Ghosh, Jeffrey T. Bolin, Lindsay D. Eltis (2013). Lid domain of the mcp hydrolase dxnb2 contributes to the reactivity toward recalcitrant pcb metabolites. Biochemistry.

DOI

Rahul Singh, Jason C. Grigg, Wei Qin, John F. Kadla, Michael E. P. Murphy, Lindsay D. Eltis (2013). Improved manganese-oxidizing activity of dypb, a peroxidase from a lignolytic bacterium. ACS Chem Biol.

DOI

Israel Casabon, Adam M. Crowe, Jie Liu, Lindsay D. Eltis (2013). Fadd3 is an acyl-coa synthetase that initiates catabolism of cholesterol rings c and d in actinobacteria. Mol Microbiol.

DOI

Paul D. Sainsbury, Elizabeth M. Hardiman, Mark Ahmad, Hiroshi Otani, Nicolas Seghezzi, Lindsay D. Eltis, Timothy D. H. Bugg (2013). Breaking down lignin to high-value chemicals: The conversion of lignocellulose to vanillin in a gene deletion mutant of rhodococcus jostii rha1. ACS Chem Biol.

DOI

Antonio C. Ruzzini, Shiva Bhowmik, Subhangi Ghosh, Katherine C. Yam, Jeffrey T. Bolin, Lindsay D. Eltis (2013). A substrate-assisted mechanism of nucleophile activation in a ser-his-asp containing c-c bond hydrolase. Biochemistry.

DOI